Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation (Advances in Predictive, Preventive and Personalised Medicine) 1st ed. 2019 Edition

Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation 1st ed. 2019 EditionUnmet healthcare needs of young populations and individuals in suboptimal health conditions are the key issue of currently observed epidemics of non-communicable disorders. Moreover, an unprecedented decrease in the average age of onset of these disorders is recorded.

Get ebook : $13.00 


The majority of non-communicable disorders carry a chronic character by progressing over a couple of years from a reversible suboptimal health condition to irreversible pathology with collateral complications. The time-frame between both conditions is the operational area for predictive diagnosis and identification of persons at risk by innovative screening programmes followed by the most cost-effective personalised treatment possible, namely primary prevention tailored to the person.

The book propagates the paradigm change from delayed, costly but frequently ineffective medical services to the holistic approach by predictive, preventive and personalised medicine clearly demonstrating multifaceted benefits to the individual, healthcare sector and society as a whole.

The book is focused on the needs of

  • young people: teenagers, adolescents and young adults;
  • regardless of the age, individuals in suboptimal health conditions, who are interested in remaining healthy by optimising their modifiable risk factors – both endogenous and exogenous ones;
  • several patient cohorts demonstrating similar phenotype of Flammer syndrome.

The book is based on the multi-professional expertise, scientific excellence and practical experiences of the world-acknowledged experts in Flammer syndrome, predictive diagnostics, targeted prevention and personalised medicine, amongst others. The topic of this book is particularly relevant to general practitioners, experts in non-communicable diseases, phenotyping, genotyping, multilevel diagnostics, targeted prevention, personalised medicine, as well as the readers interested in advancing their health literacy.

Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation 1st ed. 2019 Edition
by Olga Golubnitschaja (Editor)
ISBN-13:
 978-3030135492
ISBN-10: 3030135497

Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation 1st ed. 2019 Edition – Contents

Flammer Syndrome in the Global Context – The “U-Shape”
of Health Risks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Olga Golubnitschaja
General Lessons Learned from Flammer Syndrome . . . . . . . . . . . . . . . . . 9
Josef Flammer and Katarzyna Konieczka
Flammer Syndrome-Affected Individuals May Be Predisposed
to Associated Pathologies Early in Life: Psychological
and Psychiatric Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
Olga Golubnitschaja, Detlef E. Dietrich, Dieter Felbel,
and Vincenzo Costigliola
Flammer Syndrome: Psychological Causes and Consequences
of Visual Impairment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Bernhard A. Sabel, Jiaqi Wang, Lizbeth Cárdenas-Morales,
Muneeb Faiq, Christine Heim, and Olga Golubnitschaja
Multiomic Signature of Glaucoma Predisposition in Flammer
Syndrome Affected Individuals – Innovative Predictive, Preventive
and Personalised Strategies in Disease Management . . . . . . . . . . . . . . . . . 79
Olga Golubnitschaja, Kristina Yeghiazaryan, and Josef Flammer
Interrelation Between Dry Mouth and Flammer Syndromes:
Neglected Risks in Youth and New Concepts
of Personalised Prevention . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105
Analtolij Kunin, Jiri Polivka Jr, Natalia Moiseeva,
and Olga Golubnitschaja
viii
Specific Symptoms of Flammer Syndrome in Women Suffering
from Vaginal Dryness: Individualised Patient Profiles, Risks
and Mitigating Measures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
Vadym Goncharenko, Rostyslav Bubnov, Jiri Polivka, Pavol Zubor,
Kamil Biringer, Tibor Bielik, Walther Kuhn, and Olga Golubnitschaja
Relevance of Flammer Syndrome to the “Sleep-Wake”
Rhythm: Possible Mechanisms, Risks and Preventive Strategies . . . . . . . . 135
Kneginja Richter, Lukas Peter, Lence Miloseva, Thomas Hillemacher,
Günter Niklewski, and Olga Golubnitschaja
Flammer Syndrome and Autoimmune Inflammatory Conditions
of the Central Nervous System: Multifactorial Interrelations . . . . . . . . . . 145
Friedemann Paul
“Young Stroke” Risks Potentially Linked to the Flammer Syndrome
Phenotype: Facts and Hypotheses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165
Jiri Polivka Jr, Jiri Polivka, Martin Pesta, Vladimir Rohan, Libuse
Celedova, Rostislav Cevela, Ondrej Topolcan, and Olga Golubnitschaja
Flammer and Sjögren Syndromes: What and Why Is
in Common? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
Babak Baban and Olga Golubnitschaja
Flammer Syndrome in the Context of Healing Impairments – Facts
and Hypotheses for Multi-professional Consideration . . . . . . . . . . . . . . . . 193
Eden Avishai and Olga Golubnitschaja
Feeling Cold and Other Underestimated Symptoms of Flammer
Syndrome in Breast Cancer Diagnostics: Is Innovative Screening
on the Horizon? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Olga Golubnitschaja, Pavol Zubor, Jiri Polivka Jr., Ivica Smokovski,
Alexandra Gondova, Petra Kasajova, Jan Danko, Milan Risteski,
Daniela Trog, Katarzyna Konieczka, and Vincenzo Costigliola
Relevance of Flammer Syndrome Phenotype to Metastatic
Breast Cancer: Risks by Pre-metastatic Systemic
Hypoxic Environment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243
Rostyslav Bubnov, Jiri Polivka Jr., Pavol Zubor, Katarzyna Konieczka,
and Olga Golubnitschaja
Individualised Patient Profile: Risk Assessment by the Patient’s
Self-Report and Potential Clinical Utility of Flammer
Syndrome Phenotype . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 265
Olga Golubnitschaja and Josef Flammer
Contents
ix
Triple-Negative Breast Cancer with Pronounced Flammer
Syndrome Phenotype – Case Report . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277
Kristina Biskupska Bodova, Zuzana Laucekova, Olga Golubnitschaja,
and Pavol Zubor
Suboptimal Health Status and Cardiovascular Deficits . . . . . . . . . . . . . . . 287
Wei Wang and Xuerui Tan
Flammer Syndrome, Disordered Eating and Microbiome:
Interrelations, Complexity of Risks and Individual Outcomes . . . . . . . . . 317
Rostyslav Bubnov and Olga Golubnitschaja
Nutritional Approach to the Common Symptoms
of Flammer Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 331
Niva Shapira
Positive Effects of Acupuncture Benefiting Individuals
with Flammer Syndrome and Patients with Associated Pathologies . . . . . 351
T. Blechschmidt, M. Krumsiek, and M. G. Todorova
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371


Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation 1st ed. 2019 Edition –About the Book Series Editor

Prof. Dr. Olga Golubnitschaja Department of Radiology, Medical Faculty of Rheinische FriedrichWilhelms-University in Bonn, Germany, has studied journalism, biotechnology and medicine and has been awarded research fellowships in Austria, Russia, UK, Germany, the Netherlands and Switzerland (early and predictive diagnostics in paediatrics, neurosciences and cancer).

Dr. Golubnitschaja is the author of more than 400 well-cited international publications (research and review articles, position papers, books and book contributions) in the innovative field of predictive, preventive and personalised medicine (PPPM) with the main research focussing on pre- and perinatal diagnostics, diagnostics of cardiovascular disease and neurodegenerative pathologies and predictive diagnostics in cancer and diabetes.

Dr. Golubnitschaja was awarded National and International Fellowship of the Alexander von Humboldt-Foundation, Highest Prize in Medicine and  Eiselsberg Prize in Austria. Since 2009, Dr. Golubnitschaja is the SecretaryGeneral of the “European Association for Predictive, Preventive and Personalised Medicine” (EPMA, Brussels) networking over 50 countries worldwide, www.epmanet.eu; Book Series Editor of Advances in Predictive, Preventive and Personalised Medicine, Springer Nature; Book Editor of Predictive Diagnostics and Personalised Treatment: Dream or Reality, Nova Science Publishers, New York 2009; Book Co-editor Personalisierte Medizin, Health Academy, Dresden 2010. xii Dr. Golubnitschaja is the European Representative in the EDR-Network at the National Institutes of Health, USA, http://edrn.nci.nih.gov/. Dr. Golubnitschaja is a Regular Reviewer for over 30 clinical and scientific journals and serves as a Grant Reviewer for the national (Ministries of Health in several European countries) and international funding bodies.

Since 2007 until the present, she works as the European Commission evaluation expert for FP7, Horizon 2020, IMI-1 (Innovative Medical Initiatives) and IMI-2. In years 2010–2013, she was involved in creating the PPPM-related contents of the EuropeanProgramme “Horizon 2020”. Currently, Dr. Golubnitschaja is the Vice-Chair of
the Evaluation Panel for Marie Curie Mobility Actions at the European Commission in Brussels.


Flammer Syndrome: From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation 1st ed. 2019 Edition – Flammer Syndrome in the Global Context – The “U-Shape” of Health Risks

Olga Golubnitschaja

Abstract Unmet healthcare needs of young populations are the key issue of currently observed epidemics of non-communicable disorders. Moreover, an unprecedented decrease in the average age of onset of these disorders is recorded.

The majority of non-communicable disorders carry a chronic character by progressing over a couple of years from a reversible suboptimal health condition to irreversible pathology with collateral complications. The time-frame between both conditions is the operational area for predictive diagnosis and identification of persons at risk by
innovative screening programmes followed by the most cost-effective personalised treatment possible, namely primary prevention tailored to the person.

Particularly in young people, both abnormally low and high BMI play an important role with longterm adverse health effects. Monitoring both underweight and overweight trends across the European countries and worldwide using data objectively measured and obtained with comparable methods, thoroughly performed analysis of the trends causality as well as follow-up mitigating programmes are essential measures which should be considered a public health priority.

In contrast to the overweight subpopulations, the causality, risks and associated pathologies linked to the underweight subpopulations are much less understood. Actual studies clearly demonstrate that thinness is an overlooked phenomenon with wide variation in prevalence and trends across developed countries. The matter
deserves longitudinal studies in multinational context to understand risk factors and to contribute to targeted preventive programmes focused on thinness and follow-up. The causality is complex……

Leave a Reply

Your email address will not be published. Required fields are marked *