Hoffbrand’s Essential Haematology, 7th Edition
The definitive haematology textbook of choice for medical students. Hoffbrand s Essential Haematology has built a reputation as the flagship haematology textbook for both students and junior doctors, providing an authoritative introduction to the subject.
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Now in its 7th edition, this classic text provides up–to–date knowledge of the pathogenesis, clinical and laboratory features, treatment of blood and bone marrow disorders, in its concise and user–friendly style.
Hoffbrand s Essential Haematology outlines the basic principles of clinical and laboratory haematology and shows how manifestations of blood diseases can be explained by new knowledge of the disease processes. It is an indispensable resource for students and trainees and an essential read for all specialists who are interested in updating their knowledge.
Hoffbrand s Essential Haematology:
Provides up–to–date knowledge of the pathogenesis, clinical and laboratory features and treatment of all blood disorders
Features detailed information on the new genetics of leukaemia and lymphoma
Includes a new chapter on thrombosis, focussing on the new oral anticoagulants
Is beautifully presented, with over 300 colour illustrations
Comprehensively covers both theory and treatment regimes
Includes a companion website at featuring all the figures and tables from the book, and over 300 interactive multiple choice questions.
Hoffbrand’s Essential Haematology (Essentials) 7th Edition
by A. Victor Hoffbrand (Author), Paul A. H. Moss (Author)
Hoffbrand’s Essential Haematology, 7th Edition – Contents
Preface to the Seventh Edition vi
Preface to the First Edition vii
How to use your textbook viii
About the companion website x
1 Haemopoiesis 1
2 Erythropoiesis and general aspects of
3 Hypochromic anaemias 27
4 Iron overload 41
5 Megaloblastic anaemias and other
macrocytic anaemias 48
6 Haemolytic anaemias 60
7 Genetic disorders of haemoglobin 72
8 The white cells 1: granulocytes,
monocytes and their benign disorders 87
9 The white cells 2: lymphocytes and
their benign disorders 102
10 The spleen 116
11 The aetiology and genetics of
haematological malignancies 122
12 Management of haematological
13 Acute myeloid leukaemia 145
14 Chronic myeloid leukaemia 156
15 Myeloproliferative disease 165
16 Myelodysplasia 177
17 Acute lymphoblastic leukaemia 186
18 The chronic lymphoid leukaemias 197
19 Hodgkin lymphoma 205
20 Non-Hodgkin lymphoma 213
21 Multiple myeloma and related
22 Aplastic anaemia and bone
marrow failure 242
23 Stem cell transplantation 250
24 Platelets, blood coagulation and
25 Bleeding disorders caused by
vascular and platelet abnormalities 278
26 Coagulation disorders 290
27 Thrombosis 1: pathogenesis and
28 Thombosis 2: treatment 311
29 Haematological changes in systemic
30 Blood transfusion 333
31 Pregnancy and neonatal haematology 346
Appendix: World Health Organization classification of
tumours of the haematopoietic and lymphoid tissues 352
Hoffbrand’s Essential Haematology, 7th Edition – Preface to the Seventh Edition
There have been remarkable advances in the understanding of the pathogenesis of diseases of the blood and lymphatic system and in the treatment of these diseases, since the 6th Edition of Essential Haematology was published in 2011. This new knowledge is due largely to the application of next generation sequencing of DNA which has enabled the detection of the genetic mutations, inherited or acquired, that underlie these diseases. As examples, sequencing has revealed the CALR mutation underlying a substantial proportion of patients with myeloproliferative diseases and the MYD88 mutation present in almost all cases of Waldenström’s macrogobulinaemia.
Multiple ‘driver’ gene mutations affecting signalling pathways and epigenetic reactions involved in cell proliferation and survival have been discovered which underlie myelodysplasia, acute myeloid and lymphoblastic leukaemias, chronic lymphocytic leukaemia and the lymphomas. The complexity of the molecular changes underlying the malignant diseases and the relevance of this to their
sensitivity or resistance to therapy is becoming apparent.
This new knowledge has been accompanied by spectacular improvements in therapy. Inhibition of
the B cell receptor signalling pathway has transformed the life expectancy in many patients with resistant chronic lymphocytic leukaemia and some of the B cell lymphomas resistant to other therapy. JAK2 inhibitors are improving the quality of life and survival in primary myelofibrosis. Survival in myeloma is improving remarkably with new proteasome inhibitory and immunomodulatory drugs.
Life expectancy has also improved for patients with diseases such as thalassaemia major receiving multiple transfusions with the worldwide introduction of orally active iron chelating agents. New anticoagulants which directly inhibit at a single point in the coagulation cascade and rarely need monitoring are now used commonly in preference to warfarin for the treatment and prevention of arterial and venous thrombosis.
These advances in knowledge have been incorporated as new text, diagrams and tables for this seventh edition. New multiple choice questions have been added to the website and short summary boxes are included at the end of each chapter.
We thank Dr Trevor Baglin for his helpful suggestions for the coagulation section of the book. We wish to thank our publishers Wiley‐Blackwell and the staff who have helped us with the production of this 7th Edition. We also thank Jane Fallows for once more producing clear, expertly drawn scientific diagrams. We hope it will be widely used both by undergraduates and by postgraduates in medicine and related sciences wishing to gain a grounding in one of the most exciting and advanced fields of medicine.
Hoffbrand’s Essential Haematology – Preface to the First Edition
The major changes that have occurred in all fields of medicine over the last decade have been accompanied by an increased understanding of the biochemical, physiological and immunological processes involved in normal blood cell formation and function and the disturbances that may occur in different diseases.
At the same time, the range of treatment available for patients with diseases of the blood and blood‐forming organs has widened and improved substantially as understanding of the disease processes has increased and new drugs and means of support care have been introduced.
We hope the present book will enable the medical student of the 1980s to grasp the essential features of modern clinical and laboratory haematology and to achieve an understanding of how many of the manifestations of blood diseases can be explained with this new knowledge of the disease processes.
We would like to thank many colleagues and assistants who have helped with the preparation of the book. In particular, Dr H.G. Prentice cared for the patients whose haematological responses are illustrated in Figs 5.3 and 7.8 and Dr J. McLaughlin supplied Fig. 8.6. Dr S. Knowles reviewed critically the final manuscript and made many helpful suggestions.
Any remaining errors are, however, our own. We also thank Mr J.B. Irwin and R.W. McPhee who drew many excellent diagrams, Mr Cedric Gilson for expert photomicrography, Mrs T. Charalambos, Mrs B. Elliot, Mrs M. Evans and Miss J. Allaway for typing the manuscript, and Mr Tony Russell of Blackwell Scientific Publications for his invaluable help and patience.
Hoffbrand’s Essential Haematology, 7th Edition – CHAPTER 1
■ Site of haemopoiesis 2
■ Haemopoietic stem and progenitor cells 2
■ Bone marrow stroma 4
■ The regulation of haemopoiesis 4
■ Haemopoietic growth factors 4
■ Growth factor receptors and signal transduction 6
■ Adhesion molecules 8
■ The cell cycle 8
■ Transcription factors 8
■ Epigenetics 8
■ Apoptosis 9
This first chapter is concerned with the general aspects of blood cell formation (haemopoiesis). The processes that regulate haemopoiesis and the early stages of formation of red cells
(erythropoiesis), granulocytes and monocytes (myelopoiesis) and platelets (thrombopoiesis) are also discussed……………….