Leukemia Stem Cells in Hematologic Malignancies (Advances in Experimental Medicine and Biology) 1st ed. 2019 Edition

Leukemia Stem Cells in Hematologic Malignancies 1st ed. 2019 EditionThis book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function.

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With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.

Leukemia Stem Cells in Hematologic Malignancies 1st ed. 2019 Edition
by Haojian Zhang (Editor), Shaoguang Li (Editor)
ISBN-13:
 978-9811373411
ISBN-10: 9811373418

Leukemia Stem Cells in Hematologic Malignancies (Advances in Experimental Medicine and Biology) 1st ed. 2019 Edition – Content

1 Signaling Pathways in Leukemic Stem Cells . . . . . . . . . . . . . . . . . . . . 1
Lindsay M. Gurska, Kristina Ames, and Kira Gritsman
2 Cellular and Molecular State of Myeloid
Leukemia Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
Xueqin Xie, Mengdie Feng, Qifan Wang, Jiazhen Wang,
Rong Yin, Yicun Li, and Haojian Zhang
3 Metabolic Regulations in Hematopoietic Stem Cells . . . . . . . . . . . . . . 59
Dan Huang, Chiqi Chen, Xiaoxin Hao, Hao Gu, Li Xie,
Zhuo Yu, and Junke Zheng
4 RNA N6
-Methyladenosine Modification in Normal
and Malignant Hematopoiesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Hengyou Weng, Huilin Huang, and Jianjun Chen
5 Leukemia Stem Cells in the Pathogenesis, Progression,
and Treatment of Acute Myeloid Leukemia . . . . . . . . . . . . . . . . . . . . . 95
Kanak Joshi, Lei Zhang, Peter Breslin S.J., and Jiwang Zhang
6 Tissue “Hypoxia” and the Maintenance of Leukemia
Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129
Persio Dello Sbarba and Giulia Cheloni
7 DNA Damage Response in Quiescent Hematopoietic
Stem Cells and Leukemia Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Wenjun Zhang, Guangming Wang, and Aibin Liang
8 Epigenetic Abnormalities in Acute Myeloid Leukemia
and Leukemia Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
Jing Xu, Xiaohang Hang, Baohong Wu, Chong Chen, and Yu Liu
viii
9 Leukemia Stem Cells in Chronic Myeloid Leukemia . . . . . . . . . . . . . 191
Yi Shan, Ngoc DeSouza, Qiang Qiu, and Shaoguang Li
10 Cellular Immunotherapy in the Treatment
of Hematopoietic Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 217
Satoko Matsueda, Thinle Chodon, and Richard C. Koya


Leukemia Stem Cells in Hematologic Malignancies (Advances in Experimental Medicine and Biology) 1st ed. 2019 Edition – Chapter 1

Signaling Pathways in Leukemic Stem
Cells
Lindsay M. Gurska, Kristina Ames, and Kira Gritsman

Contents
1.1 Introduction 3
1.2 The PI3K/AKT/mTOR Signaling Pathway 5
1.3 The PI3K Isoforms in HSCs and in Leukemia 7
1.4 AKT in HSCs and Leukemia 8
1.5 The Phosphatases PTEN and SHIP in HSCs and LSCs 10
1.6 PDK1 in HSCs and Leukemia 12
1.7 mTOR in HSCs and Leukemia 13
1.8 The FOXO Transcription Factors in HSCs and Leukemia 14
1.9 Integration of PI3K/AKT with the MAPK Pathway in HSCs and LSCs 15
1.10 The WNT/β-Catenin Signaling Pathway in HSCs and LSCs 16
1.11 The NOTCH Pathway in HSCs and LSCs 20
1.12 The TGFβ Pathway in HSCs and LSCs 24
1.13 Concluding Remarks 28
References 30

Abstract Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) utilize many of the same signaling pathways for their maintenance and survival. In this review, we will focus on several signaling pathways whose roles have been extensively studied in both HSCs and LSCs. Our main focus will be on the PI3K/AKT/mTOR pathway and several of its regulators and downstream effectors.

We will also discuss several other signaling pathways of particular importance in LSCs, including the WNT/β-catenin pathway, the NOTCH pathway, and the TGFβ pathway…

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