The MD Anderson Manual of Medical Oncology, Third Edition (M.D. Anderson Manual of Medical Oncology) 3rd Edition

The MD Anderson Manual of Medical Oncology, Third Edition (M.D. Anderson Manual of Medical Oncology)Authoritative, hands-on desk reference for the practicing oncologist—from the leader in the field of cancer management and treatment
A Doody’s Core Title for 2019!

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The MD Anderson Manual of Medical Oncology details the personalized multidisciplinary approach to cancer management and treatment of common and rare cancers pioneered by The University of Texas MD Anderson Cancer Center. Its pragmatic presentation can provide valuable insights at any stage of your career.
This completely updated third edition reflects the most recent advancements, including expanded coverage of the rapidly evolving area of biological and immune therapies of cancer, many developed at MD Anderson. It emphasizes and discusses continuing developments in diagnostic procedures, which include the incorporation of new molecular markers and revised staging systems. It also reinforces how imaging and molecular profiling can prevent administration of overly aggressive, toxic treatment regimens or invasive surgery to treat superficial or indolent tumors.
To help you quickly assess cancer management options, every chapter includes numerous tables, diagrams, imaging photographs, and prescriptive advice. Evidence-based treatment algorithms in the form of flowcharts and diagrams shaped by the clinical experience of MD Anderson’s world-class faculty enhance the text.The third edition features important new chapters on key topics such as:
· Pediatric Cancers
· Molecular Biomarkers and Cancer
· Immuno-Oncology
· Targeted Therapies in Cancer
· Onco-Cardiology
· Pulmonary Complications of Cancer Therapy
· Applied Biostatistics
Offering the perfect balance of narrative text, summary tables, and clinical photographs (many in full color), there is truly not a more accessible, up-to-date, or authoritative clinician’s guide to the medical management of patients with cancer and its complications than The MD Anderson Manual of Medical Oncology.


Contributors xi
A Brief History of MD Anderson Cancer Center xxi
Foreword xxv
Preface xxvii
Section Editor: William G. Wierda
1. Acute Lymphoblastic Leukemia 3
Muhamed Baljevic, Elias Jabbour, Susan O’Brien, Hagop M.
2. Adult Acute Myeloid Leukemia 19
Jasleen K. Randhawa, Joseph Khoury, Farhad RavandiKashani
3. Chronic Lymphocytic Leukemia and Associated
Disorders 41
Nitin Jain, Carlos Bueso-Ramos, Susan O’Brien, William G.
4. Chronic Myeloid Leukemia 61
Muhamed Baljevic, Elias Jabbour, Jorge Cortes, Hagop M.
5. Myelodysplastic Syndromes: The MD Anderson
Cancer Center Approach 81
Carlos Bueso-Ramos, Guillermo Garcia-Manero
6. Philadelphia Chromosome-Negative
Myeloproliferative Neoplasms 103
Srdan Verstovsek, Kate J. Newberry, Hesham M. Amin
Section Editor: Nathan H. Fowler
7. Indolent Lymphomas 133
Loretta J. Nastoupil, Chan Yoon Cheah, L. Jeffrey Medeiros,
Nathan H. Fowler
8. Aggressive B-Cell Lymphomas 153
Jason R. Westin, Sergej N. Konoplev, Luis E. Fayad, L. Jeffrey
9. T-Cell Lymphomas 181
Dai Chihara, Casey Wang, Madeleine Duvic, L. Jeffrey
Medeiros, Yasuhiro Oki
10. Hodgkin Lymphoma 201
Dai Chihara, Fredrick B. Hagemeister, L. Jeffrey Medeiros,
Michelle L. Fanale
11. Multiple Myeloma and Other Plasma Cell
Dyscrasias 229
Hans C. Lee, Krina Patel, Piyanuch Kongtim, Simrit Parmar,
Pei Lin, Muzaffar H. Qazilbash, Sheeba Thomas, Elisabet E.
Section Editor: Elizabeth J. Shpall
12. Autologous Hematopoietic Progenitor Cell
Transplantation 257
Riad El Fakih, Nina Shah, Yago Nieto
13. Allogeneic Transplantation 267
Jonathan E. Brammer, Borje S. Andersson, Chitra Hosing
14. Alternative Donor Transplants: Cord Blood
Transplant 291
Rohtesh S. Mehta, Betul Oran, Elizabeth J. Shpall
15. Alternative Donor Transplants: Haploidentical
Hematopoietic Stem Cell Transplantation 301
Sameh Gaballa, Richard E. Champlin, Stefan O. Ciurea
16. Cellular Therapy in Allogeneic Hematopoietic
Cell Transplantation 307
Philip A. Thompson, Katayoun Rezvani, Partow Kebriaei
Section Editor: Bonnie S. Glisson
17. Small Cell Carcinoma of the Lung 323
Tina Cascone, Kathryn A. Gold, Bonnie S. Glisson
18. Non–Small Cell Lung Cancer 343
Diogo Bugano Diniz Gomes, Kathryn A. Gold, Don L. Gibbons,
Commentary: George A. Eapen
viii Contents
Section Editor: Bonnie S. Glisson
19. Head and Neck Cancer 379
Jennifer McQuade, G. Brandon Gunn, William Nassib William
Jr , Merrill S. Kies
Section Editor: Robert A. Wolff
20. Gastric, Gastroesophageal Junction, and
Esophageal Cancers 401
Elena Elimova, Roopma Wadhwa, Nikolaos Charalampakis,
Alexandria T. Phan, Prajnam Das, M. Blum Murphy
21. Pancreatic Cancer 439
Jennifer B. Goldstein, Rachna T. Shroff, Robert A. Wolff,
Milind M. Javle
22. Hepatocellular Carcinoma 463
Marc Uemura, Sunil Krishnan, Ahmed O. Kaseb, Nishin A.
Bhadkamkar, Milind M. Javle, Rony Avritscher
23. Small Bowel Cancer and Appendiceal
Tumors 479
Michael J. Overman, Kanwal Raghav, Christopher Lieu,
Commentary: Keith F. Fournier
24. Colorectal Cancer 501
Van Morris, Ishwaria M. Subbiah, Scott Kopetz, Cathy Eng
25. Anal Cancer 525
Van Morris, Christopher Crane, Cathy Eng
26. Neuroendocrine Tumors 537
Daniel M. Halperin, James C. Yao
Section Editor: Gabriel N. Hortobagyi
27. Early-Stage and Locally Advanced Breast
Cancer 551
Aron S. Rosenstock, Gabriel N. Hortobagyi
28. Metastatic Breast Cancer 573
Meghan Karuturi, Vicente Valero, Mariana ChavezMacGregor
29. Inflammatory Breast Cancer 599
Tamer M. Fouad, Vicente Valero, Naoto T. Ueno
30. Special Situations in Breast Cancer 623
Stacy Moulder-Thompson, Zahi Mitri
Section Editor: Karen H. Lu
31. Ovarian Cancer 641
Kari L. Ring, Jubilee Brown, Amir A. Jazaeri
32. Tumors of the Uterine Corpus 665
Michaela A. Onstad, Janelle B. Pakish, Karen H. Lu
33. Tumors of the Uterine Cervix 689
Maria D. Iniesta, Kathleen M. Schmeler,
Pedro T. Ramirez
34. Gestational Trophoblastic Disease 709
Jubilee Brown
Section Editor: Nizar M. Tannir
35. Renal Cell Carcinoma 733
Matthew T. Campbell, Eric Jonasch, Christopher G. Wood,
Nizar M. Tannir
36. Bladder Cancer 753
Arlene Siefker-Radtke, Bogdan A. Czerniak, Colin P. N. Dinney,
Commentary: David J. McConkey
37. Prostate Cancer 773
Mehmet A. Bilen, Christopher J. Logothetis, Paul G. Corn
38. Penile Cancer 793
Lance C. Pagliaro
39. Testicular Cancer 807
Lance C. Pagliaro, Maryam N. Shafaee, Nizar M. Tannir
Section Editors: John de Groot and Michael Fisch
40. Tumors of the Central Nervous System 829
Shiao-Pei Weathers, Barbara O’Brien, John de Groot,
Commentary: Anita Mahajan, Commentary: Sujit S. Prabhu
Section Editors: Michael A. Davies and Sapna P. Patel
41. Melanoma 857
Dae Won Kim, Jeffrey E. Gershenwald, Sapna P. Patel, Michael
A. Davies
Contents ix
42. Soft Tissue and Bone Sarcomas 875
J. Andrew Livingston, Anthony Conley, Vinod Ravi,
Shreyaskumar Patel
Section Editors: Michael Fisch and John de Groot
43. Endocrine Malignancies 903
Lily Kwatampora, Steven Weitzman,
Mouhammed Habra, Naifa L. Busaidy
44. The Acquired Immunodeficiency
Syndrome–Related Cancers 933
Adan Rios, Fredrick B. Hagemeister
Section Editors: Apostolia-Maria Tsimberidou and
Nizar M. Tannir
45. Carcinoma of Unknown Primary 961
Gauri R. Varadhachary
46. Pediatric Cancers 977
Ryuma Tanaka, Patrick A. Zweidler-McKay
47. Cancer Genomics 985
Jennifer Goldstein, Zhijing Zhang, Andy Futreal
48. Immuno-Oncology 995
Sangeeta Goswami, James P. Allison, Padmanee Sharma
49. Targeted Therapy in Cancer 1003
Apostolia-Maria Tsimberidou
50. Applied Biostatistics 1021
Xuelin Huang
Section Editor: Karen H. Lu
51. Fungal and Viral Infections in Cancer
Patients 1031
Bruno P. Granwehr, Roy F. Chemaly, Dimitrios P. Kontoyiannis
52. Endocrine and Metabolic Complications of
Cancer Therapy 1055
Levent Ozsari, Naifa Lamki Busaidy,
Mouhammed Amir Habra
53. Oncologic Emergencies 1073
Sai-Ching Jim Yeung, Ellen F. Manzullo
54. Onco-Cardiology 1099
Elie Mouhayar, Danielle El-Haddad, Peter Kim, Kara
55. Pulmonary Complications
of Cancer Therapy 1121
Saadia A. Faiz, Horiana B. Grosu, Vickie R. Shannon
56. Cancer-Associated Thrombosis 1147
Rachel A. Sanford, Michael H. Kroll
Section Editors: Eduardo Bruera and Michael Fisch
57. Palliative and Supportive Care 1159
David Hui, Eduardo Bruera
58. Pain Management and
Symptom Control 1169
Kaoswi Shih, Rony Dev, Suresh K. Reddy
59. Rehabilitation 1189
Sunny S. Dhah, Jack B. Fu, Ki Y. Shin
60. Long-Term Survivorship in Adult and
Pediatric Cancer 1211
Ravin Ratan, Joann Ater, Alyssa G. Rieber,
Maria Alma Rodriguez

Index 1227

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